OUR PRODUCTS
SAFE customize diets with tamoxifen to activate CreER. We also make doxycycline diets for tet regulated systems. The Cre/lox site-specific recombination system has emerged as a mean for the generation of conditional somatic mouse GMO. This method allows one to control gene activity in space and time in almost any tissue of the mouse.
| Code | Aliments | Avantages | Dose de tamoxifène par jour en mg/kg de poids corporel (20g BW & 3.2g ingéré) |
|---|---|---|---|
| U8200 Version 0169 | A03 at 0.25g/Kg TAMOXIFEN | Aliment Standard | 40 |
| U8200 Version 0143 | A03 at 0.5g/Kg TAMOXIFEN | Aliment Standard | 80 |
| U8404 Version 0008 | 150 at 0.25g/Kg TAMOXIFEN | Sans soja et sans Luzerne | 40 |
| U8404 Version 0009 | 150 at 0.5g/Kg TAMOXIFEN | Sans soja et sans Luzerne | 80 |
| U8978 Version 0056 | AIN-93G at 0.25g/Kg TAMOXIFEN | Contiens peu d' Isoflavones | 40 |
| U8978 Version 0057 | AIN-93G at 0.5g/Kg TAMOXIFEN | Contiens peu d' Isoflavones | 80 |
| Dose modifiée selon vos besoins. | |||
All these diets have tamoxifen. SAFE supplies the tamoxifen.
The Tamoxifen citrate form is different with only 66% tamoxifen, both forms are effective but the citrate form is not provided by SAFE.
Why in diets?
Rodents are sensitive to metallic tamoxifen taste. This induce a low intake (3g diet/day), and a potential weight loss (10%) on the first days. To limit these effects, 5% sugar is added as a flavor enhancer at all tamoxifen diets.
Nevertheless, feed aversion may still occur, also it’s recommended to make a daily observation of animal tolerance. For the welfare of rodents and for limit weight loss, the protocol should alternate 2 weeks of treatment and one week off. Prefer standard diet on weekends.
| Dosage via | Avantages | Désavantages |
|---|---|---|
| Aliment | Peu stressant pour les animaux Peu de travail | La dose dépends du comportement alimentaire L'induction est plus longue que par IP |
| Eau de boisson | Peu stressant pour les animaux Peu de travail | Insoluble dans l'eau <0.1% à 20 °C La dose dépend du comportement à la boisson L'induction est plus longue que par IP |
| Injection Intrapéritonéale (IP) | Dosage précis | Méthode stressante pour les rongeurs Nécessite un manipulateur qualifié |
Useful informations
- Store diet at +4°C and plan to use it within BBD (six months)
- Keep away of natural light, Tamoxifen is sensitive to UV
- Minimum order quantity is 10 kg
- Irradiation 10 kGy or 25 kGy is possible on request
Learn more about the model tamoxifen :
- See at Methods in Molecular Biology 530:343-63 · February 2009 DOI: 10.1007/978-1-59745-471-1_18 PubMed
- Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor, meaning it is a mixed estrogen agonist and antagonist.
- Pure tamoxifen dose commonly used are 250 mg or 500 mg.
- Tamoxifen diets contains Tamoxifen. The molecule is diluted in diets but Personal Protective Equipment is recommended: Eyeshields, Lab coat, Gloves, Face particle respirator or Mask