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SAFE customize diets with tamoxifen to activate CreER. We also make doxycycline diets for tet regulated systems. The Cre/lox site-specific recombination system has emerged as a mean for the generation of conditional somatic mouse GMO. This method allows one to control gene activity in space and time in almost any tissue of the mouse.

CodeDietsAdvantagesDaily dose of tamoxifen in mg / kg body weight
(20 g BW and 3.2 g ingested)
E8220 Version 0352A04 at 0.25g/Kg TAMOXIFENStandard diet40
E8220 Version 0366A04 at 0.5g/Kg TAMOXIFENStandard diet80
U8404 Version 0008150 at 0.25g/Kg TAMOXIFENWithout soy and without alfalfa40
U8404 Version 0009150 at 0.5g/Kg TAMOXIFENWithout soy and without alfalfa80
U8978 Version 0056AIN-93G at 0.25g/Kg TAMOXIFENContains few isoflavones40
U8978 Version 0057AIN-93G at 0.5g/Kg TAMOXIFENContains few isoflavones80
Doses modified according to your needs.

All these diets have tamoxifen. SAFE supplies the tamoxifen.

The Tamoxifen citrate form is different with only 66% tamoxifen, both forms are effective but the citrate form is not provided by SAFE.

Why in diets?

Rodents are sensitive to metallic tamoxifen taste. This induce a low intake (3g diet/day), and a potential weight loss (10%) on the first days. To limit these effects, 5% sugar is added as a flavor enhancer at all tamoxifen diets.
Nevertheless, feed aversion may still occur, also it’s recommended to make a daily observation of animal tolerance. For the welfare of rodents and for limit weight loss, the protocol should alternate 2 weeks of treatment and one week off. Prefer standard diet on weekends.

Dosing viaAdvantagesDisadvantages
DietNot very stressful for animals
Little work
The dose depends on the eating behavior
Induction is longer than IP
Drinking waterNot very stressful for animals
Little work
Insoluble in water <0.1% at 20 ° C
The dose depends on the consumption behavior
Induction is longer than IP
Intraperitoneal injection (IP)Accurate dosingStressful method for rodents that requires an expert manipulator

Useful informations

  • Store diet at +4°C and plan to use it within BBD (six months)
  • Keep away of natural light, Tamoxifen is sensitive to UV
  • Minimum order quantity is 10 kg
  • Irradiation 10 kGy or 25 kGy is possible on request
  • >> Precautionary principles <<

Learn more about the model tamoxifen :

  • See at Methods in Molecular Biology 530:343-63 · February 2009 DOI: 10.1007/978-1-59745-471-1_18 PubMed
  • Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor, meaning it is a mixed estrogen agonist and antagonist.
  • Pure tamoxifen dose commonly used are 250 mg or 500 mg.
  • Tamoxifen diets contains Tamoxifen. The molecule is diluted in diets but Personal Protective Equipment is recommended: Eyeshields, Lab coat, Gloves, Face particle respirator or Mask

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